Pandemics & Infectious Diseases
Medical Treatment & Drug Development
Ph.D
France
2011.08.31
Identification of new inhibition mechanisms against viral infections: targeting the conformational transition of the envelope protein leading to virus entry; application to Dengue virus
The goal of my research is to identify possible inhibitors of Dengue virus, specifically targeting the envelope protein to block the infection process. Dengue fever is a tropical disease affecting 100 million persons per year, with around 50,000 lethal cases. A strategy designed at the laboratory will be used to identify inhibitors. It focuses on the functional analysis of the target in order to achieve maximal efficacy of the virtual screening process. A list of compounds will be ordered for in vitro testing, and promising ones will be optimized and tested on mices.
A spoke in the wheel of dengue infection
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Nathan
DESDOUITS
Institution
Institut Pasteur
Country
France
Nationality
French
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